VWF propeptide and ratios between VWF, VWF propeptide, and FVIII in the characterization of type 1 von Willebrand disease

During posttranslational modifications of von Willebrand factor (VWF), the VWF propeptide (VWFpp) is cleaved. The ratio between VWFpp and VWF antigen (VWF:Ag) and the ratio between factor VIII (FVIII:C) and VWF:Ag may be used to assess synthesis and clearance of VWF. We analyzed the contribution of...

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Autores principales: Eikenboom, Jeroen, Federici, Augusto B., Dirven, Richard J., Castaman, Giancarlo, Rodeghiero, Francesco, Budde, Ulrich, Schneppenheim, Reinhard, Batlle, Javier, Canciani, Maria Teresa, Goudemand, Jenny, Peake, Ian, Goodeve, Anne, Tosetto, Alberto, Meyer, Dominique, Fressinaud, Edith, Mazurier, Claudine, Ingerslev, Jørgen, Vorlova, Zdena, Habart, David, Holmberg, Lars, Lethagen, Stefan, Pasi, John, Hill, Frank
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society of Hematology 2013
Materias:
Thrombosis and Hemostasis
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4191434/
https://ncbi.nlm.nih.gov/pubmed/23349392
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2012-09-455089
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