Chuvash polycythemia VHL(R200W) mutation is associated with down-regulation of hepcidin expression

Hypoxia is known to reduce the expression of hepcidin, the master regulator of iron metabolism. However, it is not clear whether this response is primarily related to increased erythropoiesis driven by hypoxically stimulated erythropoietin or to a more direct effect of hypoxia on hepcidin expression...

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Hlavní autoři: Gordeuk, Victor R., Miasnikova, Galina Y., Sergueeva, Adelina I., Niu, Xiaomei, Nouraie, Mehdi, Okhotin, Daniel J., Polyakova, Lydia A., Ammosova, Tatiana, Nekhai, Sergei, Ganz, Tomas, Prchal, Josef T.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society of Hematology 2011
Témata:
Red Cells, Iron, and Erythropoiesis
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3217409/
https://ncbi.nlm.nih.gov/pubmed/21876117
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2011-03-345512
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