Chuvash polycythemia VHL(R200W) mutation is associated with down-regulation of hepcidin expression

Hypoxia is known to reduce the expression of hepcidin, the master regulator of iron metabolism. However, it is not clear whether this response is primarily related to increased erythropoiesis driven by hypoxically stimulated erythropoietin or to a more direct effect of hypoxia on hepcidin expression...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Gordeuk, Victor R., Miasnikova, Galina Y., Sergueeva, Adelina I., Niu, Xiaomei, Nouraie, Mehdi, Okhotin, Daniel J., Polyakova, Lydia A., Ammosova, Tatiana, Nekhai, Sergei, Ganz, Tomas, Prchal, Josef T.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society of Hematology 2011
Gaiak:
Red Cells, Iron, and Erythropoiesis
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3217409/
https://ncbi.nlm.nih.gov/pubmed/21876117
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2011-03-345512
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