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Chuvash polycythemia VHL(R200W) mutation is associated with down-regulation of hepcidin expression

Hypoxia is known to reduce the expression of hepcidin, the master regulator of iron metabolism. However, it is not clear whether this response is primarily related to increased erythropoiesis driven by hypoxically stimulated erythropoietin or to a more direct effect of hypoxia on hepcidin expression...

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Main Authors: Gordeuk, Victor R., Miasnikova, Galina Y., Sergueeva, Adelina I., Niu, Xiaomei, Nouraie, Mehdi, Okhotin, Daniel J., Polyakova, Lydia A., Ammosova, Tatiana, Nekhai, Sergei, Ganz, Tomas, Prchal, Josef T.
格式: Artigo
語言:Inglês
出版: American Society of Hematology 2011
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC3217409/
https://ncbi.nlm.nih.gov/pubmed/21876117
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2011-03-345512
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