Chuvash polycythemia VHL(R200W) mutation is associated with down-regulation of hepcidin expression

Hypoxia is known to reduce the expression of hepcidin, the master regulator of iron metabolism. However, it is not clear whether this response is primarily related to increased erythropoiesis driven by hypoxically stimulated erythropoietin or to a more direct effect of hypoxia on hepcidin expression...

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Detalhes bibliográficos
Main Authors: Gordeuk, Victor R., Miasnikova, Galina Y., Sergueeva, Adelina I., Niu, Xiaomei, Nouraie, Mehdi, Okhotin, Daniel J., Polyakova, Lydia A., Ammosova, Tatiana, Nekhai, Sergei, Ganz, Tomas, Prchal, Josef T.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2011
Assuntos:
Red Cells, Iron, and Erythropoiesis
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3217409/
https://ncbi.nlm.nih.gov/pubmed/21876117
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2011-03-345512
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