Chuvash polycythemia VHL(R200W) mutation is associated with down-regulation of hepcidin expression

Hypoxia is known to reduce the expression of hepcidin, the master regulator of iron metabolism. However, it is not clear whether this response is primarily related to increased erythropoiesis driven by hypoxically stimulated erythropoietin or to a more direct effect of hypoxia on hepcidin expression...

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Главные авторы: Gordeuk, Victor R., Miasnikova, Galina Y., Sergueeva, Adelina I., Niu, Xiaomei, Nouraie, Mehdi, Okhotin, Daniel J., Polyakova, Lydia A., Ammosova, Tatiana, Nekhai, Sergei, Ganz, Tomas, Prchal, Josef T.
Формат: Artigo
Язык:Inglês
Опубликовано: American Society of Hematology 2011
Предметы:
Red Cells, Iron, and Erythropoiesis
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3217409/
https://ncbi.nlm.nih.gov/pubmed/21876117
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2011-03-345512
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