Altered cytokine profiles in patients with Chuvash polycythemia

Chuvash polycythemia results from a homozygous 598C>T mutation in exon 3 of the von Hippel-Lindau (VHL) gene. This disrupts the normoxia pathway for degrading hypoxia inducible factor (HIF)-1α and HIF-2α causing altered expression of HIF-1 and HIF-2 inducible genes. As hypoxia induces expression...

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Main Authors: Niu, Xiaomei, Miasnikova, Galina Y., Sergueeva, Adelina I., Polyakova, Lydia A., Okhotin, Daniel J., Tuktanov, Nikolai V., Nouraie, Mehdi, Ammosova, Tatiana, Nekhai, Sergei, Gordeuk, Victor R.
格式: Artigo
語言:Inglês
出版: 2009
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2857756/
https://ncbi.nlm.nih.gov/pubmed/19062180
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ajh.21327
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