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Design, synthesis and biological evaluation of a novel series of bisintercalating DNA-binding piperazine-linked bisanthrapyrazole compounds as anticancer agents

A series of bisintercalating DNA binding bisanthrapyrazole compounds containing piperazine linkers were designed by molecular modeling and docking techniques. Because the anthrapyrazoles are not quinones they are unable to be reductively activated like doxorubicin and other anthracyclines and thus t...

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書誌詳細
主要な著者: Zhang, Rui, Wu, Xing, Yalowich, Jack C., Hasinoff, Brian B.
フォーマット: Artigo
言語:Inglês
出版事項: 2011
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3212645/
https://ncbi.nlm.nih.gov/pubmed/22041173
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2011.10.012
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