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The structure-based design, synthesis and biological evaluation of DNA-binding bisintercalating bisanthrapyrazole anticancer compounds

Anticancer drugs that bind to DNA and inhibit DNA-processing enzymes represent an important class of anticancer drugs. In order to find stronger DNA binding and more potent cytotoxic compounds, a series of ester-coupled bisanthrapyrazole derivatives of 7-chloro-2-[2-[(2-hydroxyethyl)methylamino]ethy...

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Detalhes bibliográficos
Main Authors: Hasinoff, Brian B., Liang, Hong, Wu, Xing, Guziec, Lynn J., Guziec, Frank S., Marshall, Kyle, Yalowich, Jack C.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2418858/
https://ncbi.nlm.nih.gov/pubmed/18258442
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2008.01.033
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