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Design, synthesis and biological evaluation of novel indolin-2-ones as potent anticancer compounds
The indolin-2-one core is a privileged structure for antitumor agents, especially kinase inhibitors. Twenty-three novel indolin-2-ones were designed by molecular dissection of the anticancer drug indirubin. Seventeen of them exhibited significant inhibition against the tested cell lines, and two of...
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| Publicado no: | Bioorg Med Chem Lett |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6432916/ https://ncbi.nlm.nih.gov/pubmed/28625363 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2017.06.019 |
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