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Homocysteine promotes human endothelial cell dysfunction via site-specific epigenetic regulation of p66shc

AIMS: Hyperhomocysteinaemia is an independent risk factor for atherosclerotic vascular disease and is associated with vascular endothelial dysfunction. Homocysteine modulates cellular methylation reactions. P66shc is a protein that promotes oxidative stress whose expression is governed by promoter m...

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Main Authors: Kim, Cuk-Seong, Kim, Young-Rae, Naqvi, Asma, Kumar, Santosh, Hoffman, Timothy A., Jung, Saet-Byel, Kumar, Ajay, Jeon, Byeong-Hwa, McNamara, Dennis M., Irani, Kaikobad
Formato: Artigo
Idioma:Inglês
Publicado: Oxford University Press 2011
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3211975/
https://ncbi.nlm.nih.gov/pubmed/21933910
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/cvr/cvr250
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