Crystallographic analysis of human hemoglobin elucidates the structural basis of the potent and dual antisickling activity of pyridyl derivatives of vanillin

Vanillin has previously been studied clinically as an antisickling agent to treat sickle-cell disease. In vitro investigations with pyridyl derivatives of vanillin, including INN-312 and INN-298, showed as much as a 90-fold increase in antisickling activity compared with vanillin. The compounds pref...

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Autori principali: Abdulmalik, Osheiza, Ghatge, Mohini S., Musayev, Faik N., Parikh, Apurvasena, Chen, Qiukan, Yang, Jisheng, Nnamani, Ijeoma, Danso-Danquah, Richmond, Eseonu, Dorothy N., Asakura, Toshio, Abraham, Donald J., Venitz, Jurgen, Safo, Martin K.
Natura: Artigo
Lingua:Inglês
Pubblicazione: International Union of Crystallography 2011
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Research Papers
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3211971/
https://ncbi.nlm.nih.gov/pubmed/22101818
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S0907444911036353
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