Crystallographic analysis of human hemoglobin elucidates the structural basis of the potent and dual antisickling activity of pyridyl derivatives of vanillin

Vanillin has previously been studied clinically as an antisickling agent to treat sickle-cell disease. In vitro investigations with pyridyl derivatives of vanillin, including INN-312 and INN-298, showed as much as a 90-fold increase in antisickling activity compared with vanillin. The compounds pref...

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Hauptverfasser: Abdulmalik, Osheiza, Ghatge, Mohini S., Musayev, Faik N., Parikh, Apurvasena, Chen, Qiukan, Yang, Jisheng, Nnamani, Ijeoma, Danso-Danquah, Richmond, Eseonu, Dorothy N., Asakura, Toshio, Abraham, Donald J., Venitz, Jurgen, Safo, Martin K.
Format: Artigo
Sprache:Inglês
Veröffentlicht: International Union of Crystallography 2011
Schlagworte:
Research Papers
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3211971/
https://ncbi.nlm.nih.gov/pubmed/22101818
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S0907444911036353
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