AMG 837: A Novel GPR40/FFA1 Agonist that Enhances Insulin Secretion and Lowers Glucose Levels in Rodents

Agonists of GPR40 (FFA1) have been proposed as a means to treat type 2 diabetes. Through lead optimization of a high throughput screening hit, we have identified a novel GPR40 agonist called AMG 837. The objective of these studies was to understand the preclinical pharmacological properties of AMG 8...

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Hlavní autoři: Lin, Daniel C.-H., Zhang, Jane, Zhuang, Run, Li, Frank, Nguyen, Kathy, Chen, Michael, Tran, Thanhvien, Lopez, Edwin, Lu, Jenny Ying Lin, Li, Xiaoyan Nina, Tang, Liang, Tonn, George R., Swaminath, Gayathri, Reagan, Jeff D., Chen, Jin-Long, Tian, Hui, Lin, Yi-Jyun, Houze, Jonathan B., Luo, Jian
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2011
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3210765/
https://ncbi.nlm.nih.gov/pubmed/22087278
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0027270
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