Discovery of AM-1638: A Potent and Orally Bioavailable GPR40/FFA1 Full Agonist

[Image: see text] GPR40 (FFA1) is a G-protein-coupled receptor, primarily expressed in pancreatic islets, the activation of which elicits increased insulin secretion only in the presence of elevated glucose levels. A potent, orally bioavailable small molecule GPR40 agonist is hypothesized to be an e...

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Detalhes bibliográficos
Main Authors: Brown, Sean P., Dransfield, Paul J., Vimolratana, Marc, Jiao, XianYun, Zhu, Liusheng, Pattaropong, Vatee, Sun, Ying, Liu, Jinqian, Luo, Jian, Zhang, Jane, Wong, Simon, Zhuang, Run, Guo, Qi, Li, Frank, Medina, Julio C., Swaminath, Gayathri, Lin, Daniel C.-H., Houze, Jonathan B.
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2012
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4025659/
https://ncbi.nlm.nih.gov/pubmed/24900539
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml300133f
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