A Potent Class of GPR40 Full Agonists Engages the EnteroInsular Axis to Promote Glucose Control in Rodents

Type 2 diabetes is characterized by impaired glucose homeostasis due to defects in insulin secretion, insulin resistance and the incretin response. GPR40 (FFAR1 or FFA1) is a G-protein-coupled receptor (GPCR), primarily expressed in insulin-producing pancreatic β-cells and incretin-producing enteroe...

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Hlavní autoři: Luo, Jian, Swaminath, Gayathri, Brown, Sean P., Zhang, Jane, Guo, Qi, Chen, Michael, Nguyen, Kathy, Tran, Thanhvien, Miao, Lynn, Dransfield, Paul J., Vimolratana, Marc, Houze, Jonathan B., Wong, Simon, Toteva, Maria, Shan, Bei, Li, Frank, Zhuang, Run, Lin, Daniel C.-H.
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2012
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3467217/
https://ncbi.nlm.nih.gov/pubmed/23056280
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0046300
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