Intratumoral De Novo Steroid Synthesis Activates Androgen Receptor in Castration Resistant Prostate Cancer and is Upregulated by Treatment with CYP17A1 Inhibitors

Relapse of castration-resistant prostate cancer (CRPC) that occurs after androgen deprivation therapy of primary prostate cancer can be mediated by reactivation of the androgen receptor (AR). One important mechanism mediating this AR reactivation is intratumoral conversion of the weak adrenal androg...

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Autori principali: Cai, Changmeng, Chen, Sen, Ng, Patrick, Bubley, Glenn J., Nelson, Peter S., Mostaghel, Elahe A., Marck, Brett, Matsumoto, Alvin M., Simon, Nicholas I., Wang, Hongyun, Chen, Shaoyong, Balk, Steven P.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2011
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3209585/
https://ncbi.nlm.nih.gov/pubmed/21868758
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-11-0532
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