Resistance to CYP17A1 inhibition with abiraterone in castration resistant prostate cancer: Induction of steroidogenesis and androgen receptor splice variants

PURPOSE: Abiraterone is a potent inhibitor of the steroidogenic enzyme CYP17A1 and suppresses tumor growth in patients with castration-resistant prostate cancer (CRPC). The effectiveness of abiraterone in reducing tumor androgens is not known, nor have mechanisms contributing to abiraterone resistan...

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Main Authors: Mostaghel, Elahe A., Marck, Brett T., Plymate, Stephen, Vessella, Robert, Balk, Stephen, Matsumoto, Alvin M., Nelson1, Peter S., Montgomery, R. Bruce
Format: Artigo
Sprog:Inglês
Udgivet: 2011
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3184252/
https://ncbi.nlm.nih.gov/pubmed/21807635
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-11-0728
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