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Largazole and Analogues with Modified Metal-Binding Motifs Targeting Histone Deacetylases: Synthesis and Biological Evaluation

The histone deacetylase inhibitor, largazole 1 was synthesized by a convergent approach which involved several efficient and high yielding single pot multistep protocols. Initial attempts using t-butyl as thiol protecting group proved problematic and synthesis was accomplished by switching to trityl...

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Bibliografiske detaljer
Main Authors: Bhansali, Pravin, Hanigan, Christin L., Casero, Robert A., Tillekeratne, L. M. Viranga
Format: Artigo
Sprog:Inglês
Udgivet: 2011
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3208063/
https://ncbi.nlm.nih.gov/pubmed/21936551
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm200432a
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