Differential regulation of self-reactivity discriminates between IgG(+) human circulating memory B cells and bone marrow plasma cells

Long-term humoral immunity is maintained by the formation of high-affinity class-switched memory B cells and long-lived antibody-secreting plasma cells. In healthy humans, a substantial fraction of IgG-positive memory B cells express self-reactive and polyreactive IgG antibodies that frequently deve...

Full description

Saved in:
Bibliographic Details
Main Authors: Scheid, Johannes F., Mouquet, Hugo, Kofer, Juliane, Yurasov, Sergey, Nussenzweig, Michel C., Wardemann, Hedda
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2011
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3207704/
https://ncbi.nlm.nih.gov/pubmed/22025722
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1113395108
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items