Differential regulation of self-reactivity discriminates between IgG(+) human circulating memory B cells and bone marrow plasma cells

Long-term humoral immunity is maintained by the formation of high-affinity class-switched memory B cells and long-lived antibody-secreting plasma cells. In healthy humans, a substantial fraction of IgG-positive memory B cells express self-reactive and polyreactive IgG antibodies that frequently deve...

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Detaylı Bibliyografya
Asıl Yazarlar: Scheid, Johannes F., Mouquet, Hugo, Kofer, Juliane, Yurasov, Sergey, Nussenzweig, Michel C., Wardemann, Hedda
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: National Academy of Sciences 2011
Konular:
Biological Sciences
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3207704/
https://ncbi.nlm.nih.gov/pubmed/22025722
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1113395108
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