Autoreactive IgG memory antibodies in patients with systemic lupus erythematosus arise from nonreactive and polyreactive precursors

Persistent autoantibody production in patients with systemic lupus erythematosus (SLE) suggests the existence of autoreactive humoral memory, but the frequency of self-reactive memory B cells in SLE has not been determined. Here, we report on the reactivity of 200 monoclonal antibodies from single I...

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Detalhes bibliográficos
Main Authors: Mietzner, Brun, Tsuiji, Makoto, Scheid, Johannes, Velinzon, Klara, Tiller, Thomas, Abraham, Klaus, Gonzalez, Jose B., Pascual, Virginia, Stichweh, Dorothee, Wardemann, Hedda, Nussenzweig, Michel C.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2008
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2474524/
https://ncbi.nlm.nih.gov/pubmed/18621685
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0803644105
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