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A checkpoint for autoreactivity in human IgM(+) memory B cell development

Autoantibodies are removed from the repertoire at two checkpoints during B cell development in the bone marrow and the periphery. Despite these checkpoints, up to 20% of the antibodies expressed by mature naive B cells in healthy humans show low levels of self-reactivity. To determine whether self-r...

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Detalhes bibliográficos
Main Authors: Tsuiji, Makoto, Yurasov, Sergey, Velinzon, Klara, Thomas, Saskia, Nussenzweig, Michel C., Wardemann, Hedda
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2006
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2118214/
https://ncbi.nlm.nih.gov/pubmed/16446381
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20052033
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