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A checkpoint for autoreactivity in human IgM(+) memory B cell development
Autoantibodies are removed from the repertoire at two checkpoints during B cell development in the bone marrow and the periphery. Despite these checkpoints, up to 20% of the antibodies expressed by mature naive B cells in healthy humans show low levels of self-reactivity. To determine whether self-r...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
The Rockefeller University Press
2006
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2118214/ https://ncbi.nlm.nih.gov/pubmed/16446381 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20052033 |
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