An LXR agonist promotes GBM cell death through inhibition of an EGFR/AKT/SREBP-1/LDLR-dependent pathway

Glioblastoma (GBM) is the most common malignant primary brain tumor of adults and one of the most lethal of all cancers. EGFR mutations (EGFRvIII) and PI3K hyperactivation are common in GBM, promoting tumor growth and survival, including through SREBP-1-dependent-lipogenesis. The role of cholesterol...

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主要な著者: Guo, Deliang, Reinitz, Felicia, Youssef, Mary, Hong, Cynthia, Nathanson, David, Akhavan, David, Kuga, Daisuke, Amzajerdi, Ali Nael, Soto, Horacio, Zhu, Shaojun, Babic, Ivan, Tanaka, Kazuhiro, Dang, Julie, Iwanami, Akio, Gini, Beatrice, DeJesus, Jason, Lisiero, Dominique D., Huang, Tiffany T., Prins, Robert M., Wen, Patrick Y., Robins, H. Ian, Prados, Michael D., DeAngelis, Lisa M., Mellinghoff, Ingo K., Mehta, Minesh P., James, C. David, Chakravarti, Arnab, Cloughesy, Timothy F., Tontonoz, Peter, Mischel, Paul S.
フォーマット: Artigo
言語:Inglês
出版事項: 2011
主題:
Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3207317/
https://ncbi.nlm.nih.gov/pubmed/22059152
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-11-0102
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