EGFR Signaling Through an Akt-SREBP-1-Dependent, Rapamycin-Resistant Pathway Sensitizes Glioblastomas to Anti-Lipogenic Therapy

Glioblastoma, the most common malignant brain tumor, is among the most lethal and difficult cancers to treat. Although epidermal growth factor receptor (EGFR) mutations are frequent in glioblastoma, their clinical relevance is poorly understood. Studies of tumors from patients treated with the EGFR-...

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Bibliografiske detaljer
Main Authors: Guo, Deliang, Prins, Robert M., Dang, Julie, Kuga, Daisuke, Iwanami, Akio, Soto, Horacio, Lin, Kelly Y., Huang, Tiffany T., Akhavan, David, Hock, M. Benjamin, Kofman, Ava A., Bensinger, Steve J., Yong, William H., Vinters, Harry V., Horvath, Steve, Watson, Andrew D., Kuhn, John G., Robins, H. Ian, Mehta, Minesh P., Wen, Patrick Y., DeAngelis, Lisa M., Prados, Michael D., Mellinghoff, Ingo K., Cloughesy, Timothy F., Mischel, Paul S.
Format: Artigo
Sprog:Inglês
Udgivet: 2009
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2978002/
https://ncbi.nlm.nih.gov/pubmed/20009104
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.2000446
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