Dipyridamole inhibits lipogenic gene expression by retaining SCAP-SREBP in the endoplasmic reticulum

Sterol regulatory element-binding proteins (SREBPs) are master transcriptional regulators of the mevalonate pathway and lipid metabolism and represent an attractive therapeutic target for lipid metabolic disorders. SREBPs are maintained in the endoplasmic reticulum in a tripartite complex with SREBP...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Cell Chem Biol
Main Authors: Esquejo, Ryan M., Roqueta-Rivera, Manuel, Shao, Wei, Phelan, Peter E., Seneviratne, Uthpala, am Ende, Christopher W., Hershberger, Paul M., Machamer, Carolyn E., Espenshade, Peter J., Osborne, Timothy F.
Format: Artigo
Jezik:Inglês
Izdano: 2020
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7897222/
https://ncbi.nlm.nih.gov/pubmed/33096051
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2020.10.003
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