Dipyridamole inhibits lipogenic gene expression by retaining SCAP-SREBP in the endoplasmic reticulum

Sterol regulatory element-binding proteins (SREBPs) are master transcriptional regulators of the mevalonate pathway and lipid metabolism and represent an attractive therapeutic target for lipid metabolic disorders. SREBPs are maintained in the endoplasmic reticulum in a tripartite complex with SREBP...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Cell Chem Biol
Egile Nagusiak: Esquejo, Ryan M., Roqueta-Rivera, Manuel, Shao, Wei, Phelan, Peter E., Seneviratne, Uthpala, am Ende, Christopher W., Hershberger, Paul M., Machamer, Carolyn E., Espenshade, Peter J., Osborne, Timothy F.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2020
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC7897222/
https://ncbi.nlm.nih.gov/pubmed/33096051
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2020.10.003
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