Dipyridamole inhibits lipogenic gene expression by retaining SCAP-SREBP in the endoplasmic reticulum

Sterol regulatory element-binding proteins (SREBPs) are master transcriptional regulators of the mevalonate pathway and lipid metabolism and represent an attractive therapeutic target for lipid metabolic disorders. SREBPs are maintained in the endoplasmic reticulum in a tripartite complex with SREBP...

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Publicat a:Cell Chem Biol
Autors principals: Esquejo, Ryan M., Roqueta-Rivera, Manuel, Shao, Wei, Phelan, Peter E., Seneviratne, Uthpala, am Ende, Christopher W., Hershberger, Paul M., Machamer, Carolyn E., Espenshade, Peter J., Osborne, Timothy F.
Format: Artigo
Idioma:Inglês
Publicat: 2020
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7897222/
https://ncbi.nlm.nih.gov/pubmed/33096051
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chembiol.2020.10.003
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