An LXR agonist promotes GBM cell death through inhibition of an EGFR/AKT/SREBP-1/LDLR-dependent pathway

Glioblastoma (GBM) is the most common malignant primary brain tumor of adults and one of the most lethal of all cancers. EGFR mutations (EGFRvIII) and PI3K hyperactivation are common in GBM, promoting tumor growth and survival, including through SREBP-1-dependent-lipogenesis. The role of cholesterol...

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Main Authors: Guo, Deliang, Reinitz, Felicia, Youssef, Mary, Hong, Cynthia, Nathanson, David, Akhavan, David, Kuga, Daisuke, Amzajerdi, Ali Nael, Soto, Horacio, Zhu, Shaojun, Babic, Ivan, Tanaka, Kazuhiro, Dang, Julie, Iwanami, Akio, Gini, Beatrice, DeJesus, Jason, Lisiero, Dominique D., Huang, Tiffany T., Prins, Robert M., Wen, Patrick Y., Robins, H. Ian, Prados, Michael D., DeAngelis, Lisa M., Mellinghoff, Ingo K., Mehta, Minesh P., James, C. David, Chakravarti, Arnab, Cloughesy, Timothy F., Tontonoz, Peter, Mischel, Paul S.
Format: Artigo
Sprog:Inglês
Udgivet: 2011
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3207317/
https://ncbi.nlm.nih.gov/pubmed/22059152
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-11-0102
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