Rho kinase regulates the survival and transformation of cells bearing oncogenic forms of KIT, FLT3 and BCR-ABL

We show constitutive activation of Rho kinase (ROCK) in cells bearing oncogenic forms of KIT, FLT3 and BCR-ABL, which is dependent on PI3K and Rho GTPase. Genetic or pharmacologic inhibition of ROCK in oncogene bearing cells impaired their growth as well as the growth of acute myeloid leukemia patie...

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Detalhes bibliográficos
Main Authors: Mali, Raghuveer Singh, Ramdas, Baskar, Ma, Peilin, Shi, Jianjian, Munugalavadla, Veerendra, Sims, Emily, Wei, Lei, Vemula, Sasidhar, Nabinger, Sarah C., Goodwin, Charles B., Chan, Rebecca J., Traina, Fabiola, Visconte, Valeria, Tiu, Ramon V., Lewis, Timothy A., Stern, Andrew M., Wen, Qiang, Crispino, John D., Boswell, H. Scott, Kapur, Reuben
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3207244/
https://ncbi.nlm.nih.gov/pubmed/21907926
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2011.07.016
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