Control of the senescence-associated secretory phenotype by NF-κB promotes senescence and enhances chemosensitivity

Cellular senescence acts as a potent barrier to tumorigenesis and contributes to the anti-tumor activity of certain chemotherapeutic agents. Senescent cells undergo a stable cell cycle arrest controlled by RB and p53 and, in addition, display a senescence-associated secretory phenotype (SASP) involv...

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Bibliographische Detailangaben
Hauptverfasser: Chien, Yuchen, Scuoppo, Claudio, Wang, Xiaowo, Fang, Xueping, Balgley, Brian, Bolden, Jessica E., Premsrirut, Prem, Luo, Weijun, Chicas, Agustin, Lee, Cheng S., Kogan, Scott C., Lowe, Scott W.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Cold Spring Harbor Laboratory Press 2011
Schlagworte:
Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3205583/
https://ncbi.nlm.nih.gov/pubmed/21979375
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.17276711
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