Trabectedin modulates the senescence-associated secretory phenotype and promotes cell death in senescent tumor cells by targeting NF-κB

Therapy-induced senescence is a major cellular response to chemotherapy in solid tumors. Senescent tumor cells acquire a secretory phenotype, or SASP, and produce pro-inflammatory factors, whose expression is largely under NF-κB transcriptional control. Secreted factors play a positive role in drivi...

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Bibliographic Details
Published in:Oncotarget
Main Authors: Camorani, Simona, Cerchia, Laura, Fedele, Monica, Erba, Eugenio, D’Incalci, Maurizio, Crescenzi, Elvira
Format: Artigo
Language:Inglês
Published: Impact Journals LLC 2018
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Research Paper
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5929437/
https://ncbi.nlm.nih.gov/pubmed/29731994
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.24961
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