Sprouty1 induces a senescence-associated secretory phenotype by regulating NFκB activity: implications for tumorigenesis

Genes of the Sprouty family (Spry1–4) are feedback inhibitors of receptor tyrosine kinase (RTK) signaling. As such, they restrain proliferation of many cell types and have been proposed as tumor-suppressor genes. Although their most widely accepted target is the Extracellular-regulated kinases (ERK)...

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Detalhes bibliográficos
Main Authors: Macià, A, Vaquero, M, Gou-Fàbregas, M, Castelblanco, E, Valdivielso, J M, Anerillas, C, Mauricio, D, Matias-Guiu, X, Ribera, J, Encinas, M
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2014
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Original Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3890957/
https://ncbi.nlm.nih.gov/pubmed/24270409
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cdd.2013.161
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