Sprouty1 Controls Genitourinary Development via its N-Terminal Tyrosine

BACKGROUND: Studies in mice suggest that perturbations of the GDNF-Ret signaling pathway are a major genetic cause of congenital anomalies of the kidney and urinary tract (CAKUT). Mutations in Sprouty1, an intracellular Ret inhibitor, results in supernumerary kidneys, megaureters, and hydronephrosis...

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Detalhes bibliográficos
Publicado no:J Am Soc Nephrol
Main Authors: Vaquero, Marta, Cuesta, Sara, Anerillas, Carlos, Altés, Gisela, Ribera, Joan, Basson, M. Albert, Licht, Jonathan D., Egea, Joaquim, Encinas, Mario
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Nephrology 2019
Assuntos:
Basic Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6683709/
https://ncbi.nlm.nih.gov/pubmed/31300484
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2018111085
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