Saccharomyces cerevisiae THI4p is a suicidal thiamin thiazole synthase

Thiamin pyrophosphate 1 (Figure 1A) is an essential cofactor in all living systems(1). Its biosynthesis involves the separate syntheses of the pyrimidine 2 and thiazole 3 precursors, which are then coupled(2). Two biosynthetic routes to the thiamin thiazole have been identified. In prokaryotes, five...

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Main Authors: Chatterjee, Abhishek, Abeydeera, N. Dinuka, Bale, Shridhar, Pai, Pei-Jing, Dorrestein, Pieter C., Russell, David H., Ealick, Steven E., Begley, Tadhg P.
Format: Artigo
Jezik:Inglês
Izdano: 2011
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3205460/
https://ncbi.nlm.nih.gov/pubmed/22031445
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature10503
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