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Biosynthesis of the Thiamin-Thiazole in Eukaryotes: Identification of a Thiazole Tautomer Intermediate

Thiamin thiazole biosynthesis in eukaryotes is still not completely understood. In this report, a late intermediate, tightly bound to the active site of the Saccharomyces cerevisiae thiazole synthase, was identified as an adenylated thiazole tautomer. The reactivity of this unusual compound was eval...

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Foilsithe in:J Am Chem Soc
Main Authors: Chatterjee, Abhishek, Schroeder, Frank C., Jurgenson, Christopher T., Ealick, Steven E., Begley, Tadhg P.
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2008
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6040654/
https://ncbi.nlm.nih.gov/pubmed/18652458
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja802140a
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