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Biosynthesis of the Thiamin Thiazole in Eukaryotes: The Conversion of NAD to an Advanced Intermediate

Thiazole synthase catalyzes the formation of the thiazole moiety of thiamin pyrophosphate. The enzyme from Saccharomyces cerevisiae (THI4) copurifies with a set of strongly bound adenylated metabolites. One of them has been characterized as the ADP adduct of 5-(2-hydroxyethyl)-4-methylthiazole-2-car...

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Main Authors: Chatterjee, Abhishek, Jurgenson, Christopher T., Schroeder, Frank C., Ealick, Steven E., Begley, Tadhg P.
Format: Artigo
Jezik:Inglês
Izdano: 2007
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2536526/
https://ncbi.nlm.nih.gov/pubmed/17309261
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja067606t
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