p53 activation of mesenchymal stromal cells partially abrogates microenvironment-mediated resistance to FLT3 inhibition in AML through HIF-1α–mediated down-regulation of CXCL12

Fms-like tyrosine kinase-3 (FLT3) inhibitors have been used to overcome the dismal prognosis of acute myeloid leukemia (AML) with FLT3 mutations. Clinical results with FLT3 inhibitor monotherapy have shown that bone marrow responses are commonly less pronounced than peripheral blood responses. We in...

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Bibliographische Detailangaben
Hauptverfasser: Kojima, Kensuke, McQueen, Teresa, Chen, Ye, Jacamo, Rodrigo, Konopleva, Marina, Shinojima, Naoki, Shpall, Elizabeth, Huang, Xuelin, Andreeff, Michael
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society of Hematology 2011
Schlagworte:
Myeloid Neoplasia
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3204912/
https://ncbi.nlm.nih.gov/pubmed/21868571
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2011-02-334136
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