Targeting FLT3-ITD signaling mediates ceramide-dependent mitophagy and attenuates drug resistance in AML

Signaling pathways regulated by mutant Fms-like tyrosine kinase 3 (FLT3)–internal tandem duplication (ITD), which mediate resistance to acute myeloid leukemia (AML) cell death, are poorly understood. Here, we reveal that pro-cell death lipid ceramide generation is suppressed by FLT3-ITD signaling. M...

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Detalles Bibliográficos
Publicado en:Blood
Main Authors: Dany, Mohammed, Gencer, Salih, Nganga, Rose, Thomas, Raquela J., Oleinik, Natalia, Baron, Kyla D., Szulc, Zdzislaw M., Ruvolo, Peter, Kornblau, Steven, Andreeff, Michael, Ogretmen, Besim
Formato: Artigo
Idioma:Inglês
Publicado: American Society of Hematology 2016
Assuntos:
Myeloid Neoplasia
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5064718/
https://ncbi.nlm.nih.gov/pubmed/27540013
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2016-04-708750
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