p53 activation of mesenchymal stromal cells partially abrogates microenvironment-mediated resistance to FLT3 inhibition in AML through HIF-1α–mediated down-regulation of CXCL12

Fms-like tyrosine kinase-3 (FLT3) inhibitors have been used to overcome the dismal prognosis of acute myeloid leukemia (AML) with FLT3 mutations. Clinical results with FLT3 inhibitor monotherapy have shown that bone marrow responses are commonly less pronounced than peripheral blood responses. We in...

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Detalhes bibliográficos
Main Authors: Kojima, Kensuke, McQueen, Teresa, Chen, Ye, Jacamo, Rodrigo, Konopleva, Marina, Shinojima, Naoki, Shpall, Elizabeth, Huang, Xuelin, Andreeff, Michael
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2011
Assuntos:
Myeloid Neoplasia
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3204912/
https://ncbi.nlm.nih.gov/pubmed/21868571
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2011-02-334136
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