Clonal drift demonstrates unexpected dynamics of the T-cell repertoire in T-large granular lymphocyte leukemia

T-cell large granular lymphocyte leukemia (T-LGLL) is characterized by chronic lymphoproliferation of cytotoxic T lymphocytes (CTLs) and is associated with lineage-restricted cytopenias. Introduction of T-cell receptor (TCR) variable β-chain (Vβ) monoclonal antibodies has facilitated identification...

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Autori principali: Clemente, Michael J., Wlodarski, Marcin W., Makishima, Hideki, Viny, Aaron D., Bretschneider, Isabell, Shaik, Mohammad, Bejanyan, Nelli, Lichtin, Alan E., His, Eric D., Paquette, Ronald L., Loughran, Thomas P., Maciejewski, Jaroslaw P.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society of Hematology 2011
Soggetti:
Immunobiology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3204910/
https://ncbi.nlm.nih.gov/pubmed/21865345
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2011-02-338517
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