Clonal drift demonstrates unexpected dynamics of the T-cell repertoire in T-large granular lymphocyte leukemia

T-cell large granular lymphocyte leukemia (T-LGLL) is characterized by chronic lymphoproliferation of cytotoxic T lymphocytes (CTLs) and is associated with lineage-restricted cytopenias. Introduction of T-cell receptor (TCR) variable β-chain (Vβ) monoclonal antibodies has facilitated identification...

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Bibliographic Details
Main Authors: Clemente, Michael J., Wlodarski, Marcin W., Makishima, Hideki, Viny, Aaron D., Bretschneider, Isabell, Shaik, Mohammad, Bejanyan, Nelli, Lichtin, Alan E., His, Eric D., Paquette, Ronald L., Loughran, Thomas P., Maciejewski, Jaroslaw P.
Format: Artigo
Language:Inglês
Published: American Society of Hematology 2011
Subjects:
Immunobiology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3204910/
https://ncbi.nlm.nih.gov/pubmed/21865345
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2011-02-338517
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