Clonal drift demonstrates unexpected dynamics of the T-cell repertoire in T-large granular lymphocyte leukemia

T-cell large granular lymphocyte leukemia (T-LGLL) is characterized by chronic lymphoproliferation of cytotoxic T lymphocytes (CTLs) and is associated with lineage-restricted cytopenias. Introduction of T-cell receptor (TCR) variable β-chain (Vβ) monoclonal antibodies has facilitated identification...

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Main Authors: Clemente, Michael J., Wlodarski, Marcin W., Makishima, Hideki, Viny, Aaron D., Bretschneider, Isabell, Shaik, Mohammad, Bejanyan, Nelli, Lichtin, Alan E., His, Eric D., Paquette, Ronald L., Loughran, Thomas P., Maciejewski, Jaroslaw P.
Format: Artigo
Jezik:Inglês
Izdano: American Society of Hematology 2011
Teme:
Immunobiology
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3204910/
https://ncbi.nlm.nih.gov/pubmed/21865345
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2011-02-338517
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