Differential IL-21 signaling in APCs leads to disparate Th17 differentiation in diabetes-susceptible NOD and diabetes-resistant NOD.Idd3 mice

Type 1 diabetes (T1D) is an autoimmune disease that shows familial aggregation in humans and likely has genetic determinants. Disease linkage studies have revealed many susceptibility loci for T1D in mice and humans. The mouse T1D susceptibility locus insulin-dependent diabetes susceptibility 3 (Idd...

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Main Authors: Liu, Sue M., Lee, David H., Sullivan, Jenna M., Chung, Denise, Jäger, Anneli, Shum, Bennett O.V., Sarvetnick, Nora E., Anderson, Ana C., Kuchroo, Vijay K.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2011
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3204832/
https://ncbi.nlm.nih.gov/pubmed/22019586
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI46187
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