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Cutting Edge: The Idd3 Genetic Interval Determines Regulatory T Cell Function through CD11b+ CD11c− APC

The Idd3 genetic interval confers protection against multiple autoimmune diseases, including type 1 diabetes and experimental autoimmune encephalomyelitis (EAE). The favored candidate gene in this interval is Il2, which is polymorphic between susceptible and resistant strains of mice. IL-2 regulates...

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Main Authors: Anderson, Ana C., Chandwaskar, Rucha, Lee, David H., Kuchroo, Vijay K.
格式: Artigo
語言:Inglês
出版: 2008
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2614216/
https://ncbi.nlm.nih.gov/pubmed/19017931
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