The BCL11B tumor suppressor is mutated across the major molecular subtypes of T-cell acute lymphoblastic leukemia

The BCL11B transcription factor is required for normal T-cell development, and has recently been implicated in the pathogenesis of T-cell acute lymphoblastic leukemia (T-ALL) induced by TLX overexpression or Atm deficiency. To comprehensively assess the contribution of BCL11B inactivation to human T...

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Detalhes bibliográficos
Main Authors: Gutierrez, Alejandro, Kentsis, Alex, Sanda, Takaomi, Holmfeldt, Linda, Chen, Shann-Ching, Zhang, Jianhua, Protopopov, Alexei, Chin, Lynda, Dahlberg, Suzanne E., Neuberg, Donna S., Silverman, Lewis B., Winter, Stuart S., Hunger, Stephen P., Sallan, Stephen E., Zha, Shan, Alt, Frederick W., Downing, James R., Mullighan, Charles G., Look, A. Thomas
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2011
Assuntos:
Lymphoid Neoplasia
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3204734/
https://ncbi.nlm.nih.gov/pubmed/21878675
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2010-11-318873
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