High frequency of PTEN, PI3K, and AKT abnormalities in T-cell acute lymphoblastic leukemia

To more comprehensively assess the pathogenic contribution of the PTEN-PI3K-AKT pathway to T-cell acute lymphoblastic leukemia (T-ALL), we examined diagnostic DNA samples from children with T-ALL using array comparative genomic hybridization and sequence analysis. Alterations of PTEN, PI3K, or AKT w...

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Detalhes bibliográficos
Main Authors: Gutierrez, Alejandro, Sanda, Takaomi, Grebliunaite, Ruta, Carracedo, Arkaitz, Salmena, Leonardo, Ahn, Yebin, Dahlberg, Suzanne, Neuberg, Donna, Moreau, Lisa A., Winter, Stuart S., Larson, Richard, Zhang, Jianhua, Protopopov, Alexei, Chin, Lynda, Pandolfi, Pier Paolo, Silverman, Lewis B., Hunger, Stephen P., Sallan, Stephen E., Look, A. Thomas
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2009
Assuntos:
Lymphoid Neoplasia
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2713461/
https://ncbi.nlm.nih.gov/pubmed/19458356
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2009-02-206722
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