Absence of Biallelic TCRγ Deletion Predicts Early Treatment Failure in Pediatric T-Cell Acute Lymphoblastic Leukemia

PURPOSE: To identify children with T-cell acute lymphoblastic leukemia (T-ALL) at high risk of induction chemotherapy failure by using DNA copy number analysis of leukemic cells collected at diagnosis. PATIENTS AND METHODS: Array comparative genomic hybridization (CGH) was performed on genomic DNA e...

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Detalhes bibliográficos
Main Authors: Gutierrez, Alejandro, Dahlberg, Suzanne E., Neuberg, Donna S., Zhang, Jianhua, Grebliunaite, Ruta, Sanda, Takaomi, Protopopov, Alexei, Tosello, Valeria, Kutok, Jeffery, Larson, Richard S., Borowitz, Michael J., Loh, Mignon L., Ferrando, Adolfo A., Winter, Stuart S., Mullighan, Charles G., Silverman, Lewis B., Chin, Lynda, Hunger, Stephen P., Sallan, Stephen E., Look, A. Thomas
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Clinical Oncology 2010
Assuntos:
Original Reports
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2940399/
https://ncbi.nlm.nih.gov/pubmed/20644084
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1200/JCO.2010.28.3390
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