An Oncogenic Super-Enhancer Formed Through Somatic Mutation of a Noncoding Intergenic Element

In certain human cancers, the expression of critical oncogenes is driven from large regulatory elements, called super-enhancers, which recruit much of the cell’s transcriptional apparatus and are defined by extensive acetylation of histone H3 lysine 27 (H3K27ac). In a subset of T-cell acute lymphobl...

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Detalhes bibliográficos
Publicado no:Science
Main Authors: Mansour, Marc R., Abraham, Brian J, Anders, Lars, Berezovskaya, Alla, Gutierrez, Alejandro, Durbin, Adam D, Etchin, Julia, Lawton, Lee, Sallan, Stephen E., Silverman, Lewis B., Loh, Mignon L., Hunger, Stephen P., Sanda, Takaomi, Young, Richard A., Look, A. Thomas
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4720521/
https://ncbi.nlm.nih.gov/pubmed/25394790
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1259037
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