An Oncogenic Super-Enhancer Formed Through Somatic Mutation of a Noncoding Intergenic Element

In certain human cancers, the expression of critical oncogenes is driven from large regulatory elements, called super-enhancers, which recruit much of the cell’s transcriptional apparatus and are defined by extensive acetylation of histone H3 lysine 27 (H3K27ac). In a subset of T-cell acute lymphobl...

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Veröffentlicht in:Science
Hauptverfasser: Mansour, Marc R., Abraham, Brian J, Anders, Lars, Berezovskaya, Alla, Gutierrez, Alejandro, Durbin, Adam D, Etchin, Julia, Lawton, Lee, Sallan, Stephen E., Silverman, Lewis B., Loh, Mignon L., Hunger, Stephen P., Sanda, Takaomi, Young, Richard A., Look, A. Thomas
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2014
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4720521/
https://ncbi.nlm.nih.gov/pubmed/25394790
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1259037
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