Hedgehog pathway mutations drive oncogenic transformation in high-risk T-cell acute lymphoblastic leukemia

The role of Hedgehog signaling in normal and malignant T-cell development is controversial. Recently, Hedgehog pathway mutations have been described in T-ALL, but whether mutational activation of Hedgehog signaling drives T-cell transformation is unknown, hindering the rationale for therapeutic inte...

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Detalhes bibliográficos
Publicado no:Leukemia
Main Authors: Burns, Melissa A., Liao, Zi Wei, Yamagata, Natsuko, Pouliot, Gayle P., Stevenson, Kristen E., Neuberg, Donna S., Thorner, Aaron R., Ducar, Matthew, Silverman, Emily A., Hunger, Stephen P., Loh, Mignon L., Winter, Stuart S., Dunsmore, Kimberly P., Wood, Brent, Devidas, Meenakshi, Harris, Marian H., Silverman, Lewis B., Sallan, Stephen E., Gutierrez, Alejandro
Formato: Artigo
Idioma:Inglês
Publicado em: 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6148437/
https://ncbi.nlm.nih.gov/pubmed/29654263
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41375-018-0097-x
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