Hedgehog pathway mutations drive oncogenic transformation in high-risk T-cell acute lymphoblastic leukemia

The role of Hedgehog signaling in normal and malignant T-cell development is controversial. Recently, Hedgehog pathway mutations have been described in T-ALL, but whether mutational activation of Hedgehog signaling drives T-cell transformation is unknown, hindering the rationale for therapeutic inte...

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Veröffentlicht in:Leukemia
Hauptverfasser: Burns, Melissa A., Liao, Zi Wei, Yamagata, Natsuko, Pouliot, Gayle P., Stevenson, Kristen E., Neuberg, Donna S., Thorner, Aaron R., Ducar, Matthew, Silverman, Emily A., Hunger, Stephen P., Loh, Mignon L., Winter, Stuart S., Dunsmore, Kimberly P., Wood, Brent, Devidas, Meenakshi, Harris, Marian H., Silverman, Lewis B., Sallan, Stephen E., Gutierrez, Alejandro
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2018
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6148437/
https://ncbi.nlm.nih.gov/pubmed/29654263
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41375-018-0097-x
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