Hedgehog pathway mutations drive oncogenic transformation in high-risk T-cell acute lymphoblastic leukemia

The role of Hedgehog signaling in normal and malignant T-cell development is controversial. Recently, Hedgehog pathway mutations have been described in T-ALL, but whether mutational activation of Hedgehog signaling drives T-cell transformation is unknown, hindering the rationale for therapeutic inte...

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Vydáno v:Leukemia
Hlavní autoři: Burns, Melissa A., Liao, Zi Wei, Yamagata, Natsuko, Pouliot, Gayle P., Stevenson, Kristen E., Neuberg, Donna S., Thorner, Aaron R., Ducar, Matthew, Silverman, Emily A., Hunger, Stephen P., Loh, Mignon L., Winter, Stuart S., Dunsmore, Kimberly P., Wood, Brent, Devidas, Meenakshi, Harris, Marian H., Silverman, Lewis B., Sallan, Stephen E., Gutierrez, Alejandro
Médium: Artigo
Jazyk:Inglês
Vydáno: 2018
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6148437/
https://ncbi.nlm.nih.gov/pubmed/29654263
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41375-018-0097-x
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