Somatic super-enhancer duplications and hotspot mutations lead to oncogenic activation of the KLF5 transcription factor

The Krüppel-like family of transcription factors (KLF) plays critical roles in human development and is associated with cancer pathogenesis. KLF5 has been shown to promote cancer cell proliferation and tumorigenesis, and to be genomically amplified in cancer cells. We recently reported that the KLF5...

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Publicat a:Cancer Discov
Autors principals: Zhang, Xiaoyang, Choi, Peter S., Francis, Joshua M., Gao, Galen F., Campbell, Joshua D., Ramachandran, Aruna, Mitsuishi, Yoichiro, Ha, Gavin, Shih, Juliann, Vazquez, Francisca, Tsherniak, Aviad, Taylor, Alison M., Zhou, Jin, Wu, Zhong, Berger, Ashton C., Giannakis, Marios, Hahn, William C., Cherniack, Andrew D., Meyerson, Matthew
Format: Artigo
Idioma:Inglês
Publicat: 2017
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5760289/
https://ncbi.nlm.nih.gov/pubmed/28963353
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/2159-8290.CD-17-0532
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